The game also supports Cross-Buy, meaning purchasing the PS4 version of the game will grant you the PS Vita version for free and vice-versa. Online is Cross-Play across the entire PlayStation family, letting you fight opponents who own either the PS3, PS4 or PS Vita version. The PS Vita version is playable on a PlayStation TV, and supports up to two local players with DualShock 3 or 4 controllers, as well as any PlayStation 3 compatible fight sticks.

Skullgirls 2nd Encore includes all of the DLC characters and stages funded by Lab Zero Games' Indiegogo campaign, as well as “All Play” multiplayer lobbies and an extensive art gallery. The Xbox versions are likely to release in early 2023. Originally, the port was 'postponed indefinitely', but after announcing additional DLC for the game, the developers have considered porting 2nd Encore to both Xbox One and Xbox Series X/S, and is currently developing the port, while also working on bringing DLC to the Switch version, which is coming in an update on January 3rd, 2023. An Xbox One port was announced the same time as the Switch port. It was released on October 22nd, 2019 by Skybound Games. However, at the Anime Expo 2018, it was revealed that the game would be coming to Nintendo Switch. The game was not released on the Nintendo 3DS, Wii U or the Xbox One due to a Nintendo platform port lacking a publisher and because of Microsoft's parity policy at the time. It is also released on April 13th, 2016 as a DLC upgrade to the original Skullgirls on Steam.

Taito Type X² Skullgirls 2nd Encore is an enhanced version of Skullgirls Encore which was released exclusively for PlayStation 4 and PlayStation Vita on July 7th, 2015.

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